LEE GORDEN

CURRICULUM VITAE DAVID LEE GORDEN, M.D., F.A.C.S.

Personal Office Address: Vanderbilt University

Medical Center Division of Hepatobiliary Surgery & Liver Transplantation 1313 21st Avenue South Suite 801, Oxford House Nashville, TN 37232-4753

Office Phone: Telephone: (615) 936-0420

Email: lee.gorden@vanderbilt.edu

Date and place of Birth: October 9, 1963, New Haven, Connecticut, U.S.A.

Education

Brown University, Providence, Rhode Island Degree: B.A., History, May 1985

Vanderbilt University School of Medicine, Nashville, Tennessee Degree: M.D., May 1990

University of Minnesota School of Medicine, Department of Internal Medicine Minneapolis, Minnesota Internship in Internal Medicine (PGY1): July 1990 – June 1991

University of Minnesota School of Medicine, Department of General Surgery Minneapolis, Minnesota Resident in General Surgery (PGY1-7): July 1991 – June 1997

Postgraduate Training

Post-doctoral Fellow, Lecturer and Teaching Assistant, University of Geneva, Department of Morphology, Centre Médical Universitaire, Geneva, Switzerland Research in Angiogenesis and Islet Transplantation July 1994—June 1996

Chief Resident in General Surgery (PGY8) University of Minnesota School of Medicine, Department of General Surgery, Minneapolis, Minnesota July 1997—June 1998

Surgical Fellow in Hepatobiliary and Pancreatic Surgery and Liver Transplantation University of Toronto, Department of Surgery, Toronto Ontario Canada, July 1999—September 2000

Minnesota Board of Medical Practice

Ontario College of Physicians and Surgeons

Diplomat American Board of Surgery

Tennessee Health Related Boards

Certified Provider for Advanced Cardiac Life Support (ACLS), and Advanced Trauma Life Support (ATLS).

Academic/Hospital Appointments

Assistant Professor of Surgery, Department of Surgery, Vanderbilt University School of Medicine Nashville, Tennessee August 2001–February 2007

Staff Surgeon, Veteran’s Administration Medical Center Nashville, Tennessee October 2001—present

Assistant Professor of Cancer Biology, Vanderbilt University School of Medicine Nashville, Tennessee September 2006—February 2007

Associate Professor of Surgery, Vanderbilt University School of Medicine Division of Hepatobiliary Surgery and Liver Transplantation Nashville, Tennessee February 2007—October 2012

Associate Professor of Cancer Biology, Faculty/Speaker Vanderbilt University School of Medicine Nashville, Tennessee February 2007—October 2012

Professor of Surgery, Vanderbilt University School of Medicine Division of Hepatobiliary Surgery and Liver Transplantation Nashville, Tennessee October 2012—present

Professor of Cancer Biology, Faculty/Speaker Vanderbilt University School of Medicine Nashville, Tennessee October 2012—present

Employment and Other Experience

Laboratory Assistant, National Institutes of Health, Bethesda, Maryland NIADDK June 1979 – January 1980

Research Assistant, Department of Morphology, University of Geneva, Geneva, Switzerland June – August 1981, June – August 1984

Student Researcher, Vanderbilt University School of Medicine, Nashville, Tennessee January 1987 – May 1987

Laboratory Assistant and Field Worker, Laboratorio di Ecologia del Benthos (oceanographic fieldstation) Stazione Zoologica di Napoli, Ischia, Italy June – August 1987

Researcher and Field Worker, medical clinic in remote Andean village as part of endemic goiter and endemic cretinism research and treatment study, Ecuador June 1985 – August 1986

Staff Surgeon, The International Surgical Team, Guatemala February 1993, 1994, 1997, 1998, 1999

Staff Surgeon, Department of Surgery, Veteran’s Administration Hospital, Minneapolis, MN July 1998 – July 1999

Advanced Laparoscopy Training, University of Washington, Seattle, WA February 1999

Advanced Laparoscopy Training, University of California, San Francisco, CA March 1999

Advanced Laparoscopy Training, Hennepin County Medical Center, Minneapolis, MN April 1999

Visiting Surgeon, Centre Hépatobiliaire, Hôpital Paul Brousse, Faculté de Médecine, Paris-Sud. 2000

Board of Directors, member, Linden Waldorf School, Nashville, TN June 2016-present

Professional Organizations

American Medical Association (AMA), 1987—1991

Vanderbilt Committee for International Medical Experience Chairman: August 1987—June 1988

Society for Surgery of the Alimentary Tract (SSAT), 1998—2002

American Association for the Study of Liver Disease (AASLD), 2001—2002

VICC Gastrointestinal Cancer Research Program, Associate Member, 2004—present

Owen H. Wangensteen Surgical Society, 2007—present

The Society of Surgical Oncology (SSO), 2007—present

The Society of University Surgeons (SUS), 2007—present American College of Surgeons (ACS), 1996—present

American Hepato-Pancreato-Biliary Association (AHPBA), 2001—present Southeastern Surgical Congress (SSC), 2001—present

American Association for Cancer Research (AACR), 2002—present

Association for Academic Surgery (AAS), 2004—present

American Society of Transplant Surgeons (ASTS), 2004—present

Nashville Surgical Society, 2004—present H. William Scott Society, 2004—present

Alpha Omega Alpha Medical Honor Society, 2005—present

Professional Activities

University Committees and Positions Faculty Student Advisor, Vanderbilt University School of Medicine, Nashville, TN July 2002 – Present

Clerkship Lecturer, Vanderbilt University Medical Center, Nashville, TN July 2002 – Present

Keynote lectureship series coordinator

Billingham Lectureship 2003 speaker Bernard Herring, M.D., Professor, University of Minnesota “Islet Transplantation.”

Norman E. Shumway Lectureship 2004 Speaker Henri Bismuth, M.D., Professor Paul Brousse, Paris, France “New Aspects of Liver Surgery”

Phillip W. Felts Lectureship 2005 Speaker Mark Earnest M.D., Associate Professor, University of Colorado “Money, Medicine, and Society”.

University Committees and Positions:

Vanderbilt-Ingram Cancer Center Member (VICC), 2004—present

Faculty Student Preceptor in Surgery, Department of Surgery, Vanderbilt University Medical Center Nashville, TN July 2007 – present

Advanced Cancer Biology Course Instructor, Vanderbilt University Medical Center, Nashville, TN September 2007 – present

Faculty Affiliate Advisor, Batson Advisory College, Vanderbilt School of Medicine Nashville, TN September 2007-2011

Advanced Cancer Biology Course Invited Lecturer, Vanderbilt University Medical Center, Nashville, TN 2006—present

Vanderbilt Department of Cancer Biology Graduate Student Mentorship Program 2007—present (Chair: Lynn Matrisian PhD)

Vanderbilt University Medical Center Transfusion Committee and Sub-Committee Member “Blood Product Utilization” Member 2011

International and National Committees

Southeastern Surgical Congress CME Committee 2004- 2009 Gold Medal Committee, member 2004—present. Chairperson, Gold Medal Forum, 2008—2009 Member of UNOS Regional Review Board, 2006, 2010, 2013 Society of University Surgeons-Member Education Committee, 2007 Fulbright Scholars and Franco-American Commission: Member Awards Selection Committee, Paris, France, 2009 Fulbright Scholars and Franco-American Commission: Solicited Expert Panel, Paris, France, 2009. National Cancer Institute (NCI), Tumor Microenvironment Network, Steering Committee Member, January 2010—January 2015 Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 6 Professional Activities (continued) International and National Committees Society of University Surgeons – Member Social and Legislative Issues Committee, 2011 – Member Education Committee, 2008. Reviewer, Abstract Review Committee for The Category ³Translational: Proteomics/Genomics Pharmacogenetics, American Society of Transplant Surgeons, 2011-2012 Board of Directors Member, Linden Waldorf School of Nashville June 2016-Present Nashville State Surgical Tech Program Advisory Committee Member, August 2016-present Honors and Awards Fellow of the American College of Surgeons (FACS) , 2003—present Alpha Omega Alpha Honor Medical Society (AOA), elected 2005 Vanderbilt Chapter for leadership in teaching and education Elliot Newman Society Charter Member, Vanderbilt University Society for Physician Scientists, 2006—present Guide to America’s Top Physicians, selected as one of “America’s Top Surgeons,” 2007 Original scientific work cited in Science article entitled: “All in the Stroma: Cancer’s Cosa Nostra,” April 4, 2008 Fulbright Scholar’s Award, Scholar in residence Paul Brousse Hospital Paris, France Awarded May 2008. Duration January 1, 2009—December 31 2009. Scientific and Clinical Mentor, Howard Hughes Medical Institute Program in Molecular Medicine, 2011—present. Five Star Clinical Excellence Award, “Top 10% nationally for clinical excellence” 2011, 2014 International Compagnons Hepatobiliare Surgical Honor Society, Invited member, Henri Bismuth (Director) May 2014-present. Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 7 Patents and Inventions U.S. Provisional Patent “Endoscopy Capsule with Site Marking Capability and Application of the Same.” Gorden, D. L. Filed August 20, 2004 (60/603,178). U.S. Patent Application. “An Endoscopy Capsule with Site Marking Capability and Application of the Same.” Gorden DL. Filed August 9, 2005. (VU Ref# 0490) (Pending). Teaching Activities Trainees Clinical: Training of surgical residents and medical students on surgery clerkships, Vanderbilt University Medical School, Nashville, TN 2001—present Research: Johnny Johnson PhD, thesis committee invited member, Stonybrook University, NY May 2007 In Kyu Lee, Postdoctoral researcher, Vanderbilt University, Nashville, TN Oct.2008—Nov.2009 Alisha Mendonsa, PhD candidate rotation student, Vanderbilt University, Nashville, TN Jan. 2010—Apr.2010 Michael Van Saun PhD; post-doc, Vanderbilt University, Nashville, TN Jan. 2008—June 2010 Alisha Mendonsa, PhD candidate, Vanderbilt University, Nashville, TN July 2010- December 2014. Graduated with PhD December 2014. Lynn Samuelson PhD, co-mentor “The Use of Backscatter Interferometry for the Identification of Biomarkers of HCC » February 2013 Arion Kennedy PhD, Co-mentor, Postdoctoral fellow. “The Role of CD8 + T Cells in Nonalcoholic Fatty Liver Disease (NAFLD)” March 2013- present Courtney Copeland, PhD qualifying exam committee member: The role of CD44v6 surface expression in the resolution of hepatic fibrosis Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 8 Research Program Grants and Funding Current OrganOx Ltd. NAMSA Role: Co-Investigator PI: Sophoclis Alexopoulos, M.D. Clinical Trial Agreement August 2017—present Octaplas Role: Co-Investigator Octapharma PI: J. Kelly Wright, Jr., M.D. Clinical Trial Agreement August 2016—present Liver Transplant Biliary Stent Study Vanderbilt University Medical Center Role: PI-Investigator August 2015—present Grants and Funding Previous “Molecular Determinants of Tumor Progression in A Steatotic Liver Microenvironment” U01 1U01CA143072-01 National Cancer Institute (NCI) Role: Principal Investigator (PI) September 29, 2009—August 31, 2015 “An Analysis of Urinary Proteases as Biomarkers For Hepatocellular Carcinoma and the Evaluation of the Response to Therapy in Patients with Hepatocellular Carcinoma” Supported in part by the Vanderbilt CTSA grant UL1 RR024975 NCRR/NIH Role: Principal investigator December 2010—present “Tumor and Stromal Metalloproteinases in Breast Cancer.” 5R01 CA084360-09 NCI Role: Co-investigator, PI: Barbara Fingleton PhD January 1, 2010—November 30, 2014 “Steatosis and Steatohepatitis Provide a Favorable Microenvironment for the Establishment and Growth of Primary Hepatocellular Carcinoma.” VUMC 2012 Transplant Center Pilot Award. Role: PI March 2012—present Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 9 Grants and Funding Previous “Hepatocellular Research Registry; CellzDirect.” CellzDirect Role: Co-Investigator PI: Sunil Geevargheese, M.D Clinical Trial Agreement April 2004—present “The Role of Matrix Metalloproteinases in the Early Stages of Colorectal Cancer Metastases to the Liver.” Vanderbilt Physician Scientist Development Program $95,000 per year July 2002—July 2004 “Mouse Models of Human Cancers Consortium – Prevention & Metastasis: Final Frontiers in Colon Cancer.” National Cancer Institute – 2U01 CA084239-06 Role: Co-Investigator , 10% Effort PI: Robert Coffey, M.D. Total Funding: $3,475,579 April 01, 2004 – March 31, 2009 “Role of Metalloproteinases in Colon Cancer Metastases.” National Institutes of Diabetes Digestive and Kidney Diseases NIDDK, 5K08DK70708-3 Role: Principal Investigator (PI) K08 September 10, 2004—December 31, 2010 “Multiphoton Microscopy of Early Tumor/Stromal Interactions in Liver Metastasis.” National Institute of Diabetes, Digestive, and Kidney Diseases NIDDK 1R03DK078711-01 Role: Principal Investigator (PI) R03 May 31, 2007—August 31, 2012 “Steatosis of the Pancreatic Microenvironment Enhances Tumor Progression.” AACR, Grant Role: Co-investigator, PI: Mike Van Saun PhD July 2010–July 2012 “Urinary Biomarkers for Hepatocellular Carcinoma.” Vanderbilt CTSA grant UL1 RR024975 from NCRR/NIH Vanderbilt University Medical Center Role: Principal Investigator (PI) March 31, 2011—March 01, 2012 “Tumor and Stromal Metalloproteinases in Breast Cancer.” 5R01 CA084360-09 NCI Role: Co-investigator, PI: Lynn Matrisian PhD January 1, 2005—December 31, 2009 Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 10 Research Program (continued) Grants and Funding Previous TGF-ß Signaling in Metastatic Colorectal Cancer: Potential for Targeting; Dates: Veterans Administration Merit Award Role: Co-investigator, PI: Pran Datta October 1, 2009—September 30, 2013 « A Prospective, Open-Label, Multi-Center, Randomized Trial of the Efficacy and Safety of a Long Term Calcineurin Inhibitor Free Maintenance Regimen with Mycophenolate Mofetil and Sirolimus in Recipients of an Orthotopic Liver Transplant. » Roche Laboratories – IRB# 050809 Role: Co – Investigator PI: John K Wright, Jr., M.D. Roche Laboratories and Vanderbilt University Medical Center Clinical Trial Agreement 2006 “Alterations in Signaling in Steatosis and Steatohepatitis.” DDRC and Vanderbilt Discovery Grant Translational Pilot and Feasibility Award Role: Principal Investigator (PI) June 2007—July 1, 2011 “Development of Imaging Strategies to Examine Microenviromental Influences in early Breast Cancer Metastasis to Liver.” Department of Defense Role: Co-Investigator, PI: Michelle Martin PhD September 01, 2009—August 31, 2010 “Recombinant Human Mannose-Binding Lectin (rhMBL).” EZN-2232-02S and EZN-2232-02 Enzon Pharmaceuticals and Vanderbilt University Medical Center Role: Co-Investigator PI: Geevarghese, Sunil Clinical Trial Agreement “A 24 Month, Multi-Center, Open-Label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Concentration-Controlled Everolimus to Eliminate or to Reduce Tacrolimus Compared to Tacrolimus in de novo Liver Transplant Recipients.” Novartis Role: Co-Investigator PI: Sunil Geevarghese, MD Clinical Trial Agreement “Tracked Ultrasound for Image-Guided Liver Surgery.” Institutional Review Board (IRB) – Vanderbilt University School of Medicine Role: Co-Investigator PI: Philip Bao, M.D. Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 11 Research Program (continued) Grants and Funding Previous “National Registry of Patients with Hepatocellular Carcinoma.” NIH Registery Role: Co-Investigator PI: Sunil Geevarghese, M.D. “Pilot Study to Assess Application of Gene Chip array Technology to Ischemia Reperfusion Injury Following Orthotopic Liver Transplantation.” Vanderbilt Univeristy Pilot Study Role: Co-Investigator PI: Ravi S. Chari, M.D. “Role of 2-[18F] Fluro-2-DeoxyGlucose Positron Emission Tomography in Determination of Post-OLTX ACR.” Vanderbilt Univeristy Pilot Study Role: Co-Investigator PI: Ravi S. Chari, M.D. “A Randomized, Open Label, Parallel-Group, Multi-Center Trial to Compare the Efficacy and Safety of TachoSil® versus Surgicel® Original for the Secondary Treatment of Local Bleeding in Adult and Pediatric Patients Undergoing Hepatic Resection Surgery.” Nycomed Role: Co-Investigator PI: J. Kelly Wright, MD Clinical Trial Agreement October 2010—2012 “Kaolin-based Gauze Hemostatic Trial (KauGHT).” Z-Medica, Elective Surgery Role: Principal Investigator January 2010—2012 “CT 1030: A Phase I/II, open-label study (with a sequential dose escalation stage followed by an expansion of a selected dose cohort), to evaluate the safety & anti-tumor effects of NV1020, administered repeatedly via hepatic artery infusion prior to second-line chemotherapy, in patients with colorectal adenocarcinoma metastatic to the liver/MediGene.” MediGene Role: Co-Investigator PI: Ravi S. Chari, M.D. “A Phase 2, Randomized, Double Blind, Study of the Safety and Efficacy of Topical rhThrombin in Subjects Undergoing Partial Hepatectomy/ZymoGenetics.” ZymoGenetics Role: Co-Investigator PI: Ravi S. Chari, M.D. Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 12 Research Program (continued) Grants and Funding Previous “A Randomized Clinical Trial Using Fibrin Sealant, Produced by the CryoSeal® FS System, in Patients Undergoing Liver Resection/ThermoGenesis.” Thermogenesis Role: Co-Investigator PI: Ravi S. Chari, M.D. Journal Editorial Review Invited Reviewer Cancer Research Molecular Cancer Research Clinical Cancer Research Transplantation Journal of Cellular Physiology Oncogene Clinical Transplantation American Journal of Transplantation Publications 1. Gorden DL. Field Guide to Parasitology. Brown University, Providence, Rhode Island. Monograph, May 1985. 2. Pacheco R, Fierro R, Yepez R, Suarez J, Rivadeneira R, Garcia J, Gorden DL. Efecto de la Utilizacion del Aceite Yodado de Depósito Sobre la Prevalencia de Bocio en un Communidad Campesina Andina. Sociedad Ecuatoriana di Biología y Pontificia, 1986. 3. Yepez R, Fierro R, Pacheco R, Suarez J, Garcia J, Gorden DL. El Niño Deprimido- Inhibido en Communidades Campesinas Andinas. Sociedad Ecuatoriana di Biológica y Pontificia, 1986. 4. Gorden DL, Robert A, Moncada V, Taylor SI, Muhlhauser J, Carpentier JL. Cell Surface Alteration in Epstein-Barr Virus-Transformed Cells from Patients with Extreme Insulin Resistance. Diabetes, 1990; 39(8):924-927. PMID 2165004 5. Gorden DL, Smith C, Graber SE. Marked Plasmacytosis and Immunoglobulin Abnormalities Following Infusion of Streptokinase. Am J Med Sci., 1991; 301(3):186-189. PMID 2000891 6. Gorden DL, Mandriota S, Montesano R, Orci L, Pepper MS. Vascular Endothelial Growth Factor is Increased in Devascularized Rat Islets of Langerhans in Vitro. Transplantation, 1997; 63(3):436- 443. PMID 9039936 Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 13 7. Beal AL, Gormley CM, Gorden DL, Ellis CM. Chylous Ascites: A Manifestation of Blunt Abdominal Trauma in an Infant. J Ped Surg., 1998; 33(4):650-652. PMID 9574772 8. Moore D, Feurer I, Speroff T, Shaffer D, Nylander W, Kizilisik T, Butler J, Awad J, Gorden DL, Chari R, Wright JK, Pinson CW. Survival and Quality of Life after Organ Transplantation in Veterans and Nonveterans. Am J Surg., 2003; 186(5):476-480. PMID 1459960 9. Moore D, Feurer I, Speroff T, Rodgers S Jr., Shaffer D, Nylander W, Kizilisik T, Butler J, Ninan M, Awad J, Gorden DL, Chari R, Wright J, Pinson CW. Is There Racial Disparity in Outcomes Following Solid Organ Transplantation? American Journal of Surgery, 2004 Nov; 188(5):571-574. PMID 15546572 10. Wagenaar-Miller RA, Gorden DL, Matrisian LM. Matrix Metalloproteinases in Colorectal Cancer: Is it Worth Talking About? Cancer and Metastasis Reviews, 2004; 23:119-135. PMID 16397239-15000153 11. Moore DE, Feurer ID, Holzman MD, Wudel LJ, Strickland C, Gorden DL, Chari R, Wright JK, Pinson CW. Long-term Detrimental Effect of Bile Duct Injury on Health-Related Quality of Life. Arch Surg., 2004; 139:476-482. PMID 15136346 12. Knox CD, Feurer ID, Wise PE, Lamps LW, Wright JK, Chari RS, Gorden DL, Pinson CW. Survival and functional quality of life after resection for hepatic carcinoid metastasis. J Gastrointest Surg., 2004;8(6):653-9. PMID 15358324 13. Anderson CD, Meranze S, Bream P Jr., Gorden DL, Wright JK, Pinson CW, Chari RS. Contralateral Portal Vein Embolization for Hepatectomy in the Setting of Hepatic Steatosis. Am Surg., 2004 Jul; 70(7):609-612. PMID 15279184 14. Kundranda M, Henderson M, Carter KJ, Gorden DL, Binhazim A, Ray S, Baptiste T, Shokrani M, Leite-Browning M, Jahnen-Dechent W, Matrisian LM, Ochieng J. “The Serum Glycoprotein Fetuin-A Promotes Lewis Lung Carcinoma Tumorigenesis via Adhesive-Dependent and Adhesive- Independent Mechanisms”. Cancer Research, January 2005; 65: (2) 499-506. PMID 15695392 15. Moore DE, Feurer ID, Speroff T, Gorden DL, Chari R, Wright JK, Pinson CW. Impact of Donor, Technical, and Recipient Risk Factors on Survival and Quality of Life after Liver Transplantation. Archives of Surgery, 2005 Mar; 140(3):273-7. PMID 15781792 16. Thomas KT, Welch D, Wise P, Gorden DL, Chari RS, Wright Jr., JK, Washington K, Pinson CW. Treatment of Biliary Cystadenoma. Annals of Surgery, 2005 May: 241(5):769-73; discussion 773-5. PMID 15849512 17. Austin MT, Feurer ID, Chari RS, Gorden DL, Wright JK, Pinson CW. “Survival After Pediatric Liver Transplantation: Why Does Living Donation Offer An Advantage?” Archives of Surgery, 2005 May:140(5):465-70; discussion 470-1. PMID 15897442 18. Acuff HB, Carter KJ, Fingleton B, Gorden DL, Matrisian LM. “MMP9 From Bone Marrow- Derived Cells Contributes to Survival But Not Growth of Tumor Cells in the Lung Microenvironment”. Cancer Research, 2006 January; 66: (1) 259-266. PMID 16397239 Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 14 19. Schrager JJ, Vnencak-Jones CL, Graber SE, Neff AT, Chari RS, Wright Jr., JK, Pinson CW, Stewart JH, Gorden DL. “Use of Short Tandem Repeats for DNA ‘Fingerprinting’ to Rapidly Diagnose Graft Versus Host Disease in Solid Organ Transplant Patients”. Transplantation, January 2006; 81(1): 21-25. PMID 16421472 20. Buchanan FG, Gorden DL, Matta P, Shi Q, Matrisian LM, DuBois RN. “Role of B-Arrestin-1 in the Metastatic Progression of Colorectal Cancer” Proceedings of the National Academy of Sciences U.S.A., January 31, 2006; 103(5) 1492-1497. PMID 16432186 21. Thomas KT, Gorden DL, Chari RS, Wright Jr. JK, Feurer ID, Pinson CW. “Biliary Reconstruction Using Non-Penetrating, Tissue Everting Clips versus Conventional Sewn Biliary Anastomosis in Liver Transplantation.” HPB, 2006; 8: 132-136. PMID 18333261 22. Castaldo ET, Pinson CW, Feurer ID, Wright Jr. JK, Gorden DL, Kelly BS, Chari RS. “Continuous vs. Interrupted Suture Technique for End-To-End Biliary Anastomosis During Liver Transplantation Give Equally Good Results.” Liver Transplantation, 2007 February; 13(2): 234-238. PMID 17256781 23. Nicoud IB, Jones CM, Pierce JM, Earl TM, Chari RS, Matrisian L, Gorden DL. “Warm Hepatic Ishcemia-Reperfusion Promotes Growth of Circulating Colorectal Carcinoma in Mouse Liver via MMP9 Induction. Cancer Research, 2007; 67(6): 2720-2728. PMID 17363593 24. Lundquist AL, Chari RS, Geevarghese SK, Kelly BS, Pinson CW, Wright Jr. JK, Gorden DL. “Serum Sickness Following Thymoglobulin Induction in a Liver Transplant Recipient: Case Report and Literature Review. Liver Transplantation, 2007; 13(5): 647-650. PMID 17377915 25. Gorden DL, Fingleton B, Crawford HC, Jansen DE, Lepage M, Matrisian LM. “Resident Stromal Cell Derived MMP-9 Promotes the Growth of Colorectal Metastases in the Liver Microenvironment” International Journal of Cancer, 2007, August 1; 121(3): 495-500. PMID 17417772 26. Koller FL, Geevarghese SK, Gorden DL. “Transplantation for Hepatocellular Carcinoma: Current Role and Future Opportunities.” Current Pharmaceutical Design 2007; November 13(32): 3265- 3271. PMID 18045177 27. Tessier DJ, Iglesias R, Chapman WC, Kercher K, Matthews BD, Gorden DL, Brunt M. « Previously Unreported High Grade Complications of Adrenalectomy » Surgical Endoscopy, 2008 Apr 29. PMID 18443863 28. Lee IK, Jung SE, Gorden DL, Lee YS, Jung DY, Oh ST, Kim JG, Jeoon HM, Chang SK. “The Diagnostic Criteria for Right Colonic Diverticulitis: Prospective Evaluation of 100 Patients.” Int J Colorectal Dis., 2008 Aug 14. PMID 18704462 29. Quarles CC, Lepage M, Gorden DL, Fingleton B, Yankeelov TE, Price RR, Matrisian LM, Gore JC, McIntyre JO. “Functional Colonography of Min Mice Using Dark Lumen Dynamic Contrast Enhanced Magnetic Resonance Imaging” Magnetic Resonance in Medicine, 2008 Sep; 60(3): 718-26. PMID 18727087 30. Castaldo ET, Earl TM, Chari RS, Gorden DL, Merchant NB, Wright Jr., JK, Feurer ID, Pinson CW. “A Clinical Comparative Analysis of Crush/Clamp, Stapler, and Dissecting Sealer Hepatic Transection Methods”. HPB (Oxford), 2008; 10(5):321-6. PMID 18982146 Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 15 31. Lee IK, Lee SK, Gorden DL, Lee YS, Jung SE, Oh ST, Kim JG, Jeon HM, Kim EK, Chang SK. “Selective Laparoscopic Management of Acute Adhesive Small Bowel Obstruction.” American Surgeon, 2009 Mar; 75(3):227-31. PMID 19350858 32. Earl TM, Nicoud IB, Pierce JN, Wright JE, Majoras N, Rubin JE, Pierre KP, Gorden DL, Chari RS. “Silencing of TLR4 Decreases Metastatic Tumor Burden in a Murine Model of Hepatic Steatosis.” Ann Surg Oncol., 2009 Apr; 16(4):1043-50. Epub 2009 Jan 23 PMID 19165543 33. Lee IK, Kim do H, Gorden DL, Lee YS, Sung NY, Park GS, Kim HJ, Kang WK, Park JK, Ahn CH, Kim JG, Jeon HM, Oh ST. Prognostic value of CEA and CA 19-9 tumor markers combined with sytology from peritoneal fluid in colorectal cancer. Ann of Surgical Onc., 2009 Apr:16(4):861- 70 Epub 2009 Feb 3. PMID 19189191 34. Adam, R, Gorden DL. Evolution of Multidisciplinary Care for Patients with Metastatic Colorectal Cancer: the “Win-Win” Combination of Surgery and Chemotherapy, Advances in Gastrointestinal Cancer, 2009 June 1. 35. VanSaun MN, Lee IK, Washington K, Matrisian LM, Gorden DL. High Fat Diet Induced Hepatic Steatosis Establishes a Permissive Microenvironment for Colorectal Metastases and Promotes Primary Dysplasia in a Murine Model. American Journal of Pathology, 2009, Jul; 175(1):355-64. PMID 19541928 36. Dixon E, Armstrong C, Maddern G, Sutherland F, Hemming, A, Wei A, Sherman M, Moore M, McKay A, Urbach D, Labrie M, Gorden DL, Barkun J, Lynn Quan M, Dowden S, Bigam D, Gallinger S. Development of Quality Indicators of Care for Patients Undergoing Hepatic Resection for Metastatic Colorectal Cancer Using a Delphi Process. Journal of Surgical Research 2009 Sep;156(1):32-38.e1. Epub 2009 May 12. PMID 19592015 37. Zhang B., Halder SK, Kashikar ND, Cho YJ, Datta A, Gorden DL, and Datta PK*. Antimetastatic Role of Smad4 Signaling in Colorectal Cancers. Gastroenterology, Epub 2009 Nov 10. PMID 19909744 38. Gregoire E; Hoti E, FRCS; Gorden DL, Pascal G, Azoulay. Utility of Prognostic Scoring Systems for Colorectal Liver Metastases in an Era of Advanced Multimodal Therapy. European Journal of Surgical Oncology. 2010;36(6):568-74 39. Bouchahda M, Karaboué A, Saffroy R, Innominato PD, Gorden DL, Guettier C, Adam R, Lévi F. Acquired KRAS Mutations During Progression of Colorectal Cancer Metastases: Possible Implications for Therapy and Prognosis. Cancer Chemotherapy Pharmacology. 2010 Aug; 66(3):605-9, Epub 2010 Apr 2. PMID 20361188 40. Petillon S, Vibert E, Gorden DL, de la Serna S, Salloum C, Azoulay D. Hepatectomy and Intrahepatic Biliary Enteric Anastomosis: A Rescue Surgery for Obstructed Metallic Biliary Stents in Chronic Pancreatitis. Gastroenterol Clin Biol., 2010 Apr 30. PMID 19189191 41. Lee IK, Lee YS, Kim SJ, Gorden DL, Won DY, Kim HJ, Cho HM, Jeon HM, Kim JG, Oh ST. Laparoscopic and Open Surgery for Right Colonic Diverticulitis. American Surgeon, 2010 May; 76(5):486-91.PMID 20506877 Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 16 42. M. Uddin, Crews B, Blobaum A, Kingsley P, Gorden DL, Mcintyre O, Matrisian L, Subbaramaiah K, Dannenberg A, Piston D, Marnett L, Selective Visualization of Cyclooxygenase-2 in Inflammation and Cancer by Targeted Fluorescent Imaging Agents, Cancer Res., 2010 May 1:70(9):3618-27. PMID 20430759 43. Kappa SF, Gorden DL, Davidson MA, Wright JK, Guillamondegui OD. Intraoperative blood loss predicts hemorrhage-related reoperation after orthotopic liver transplantation. American Surgeon. 2010 Sep;76(9):969-73 PMID 20836345 44. Martin MD, Kremers JG, Rocheleau JV, Xu L, Piston DW, Matrisian L, Gorden DL. Analysis of the Establishment and Progression of Breast Cancer Micrometastases Following Early Extravasation in the Liver Microenvironment. Molecular Cancer Research, 2010 Oct; 8 (10): 1319-27. Epub 2010 Aug 19 PMID20724460 45. Wicherts DM, Haas RJ, Gorden DL, Lévi F, Paule B, Azoulay A, Castaing D, Adam R. Impact of Bevacizumab on Functional Recovery and Histology of the Liver After Resection of Colorectal Metastases. British Journal of Surgery, Article first published online: 15 Dec 2010 doi: 10.1002/bjs.7368 46. Levi, Francis; Karaboué, Abdoulaye; Gorden, DL; Innominato, Pasquale; Saffroy, Raphael; Giacchetti, Sylvie; Hauteville, Dominique; Guettier, Catherine; Adam, René; Bouchahda, Mohamed Cetuximab and circadian chronomodulated chemotherapy as salvage treatment for metastatic colorectal cancer (mCRC): safety, efficacy and improved secondary surgical resectability. Cancer Chemotherapy and Pharmacology, 2011 Feb; 67(2):339-48Epub 2010 Apr17. PMID 20401611 47. Gorden DL, Ivanova PT, Myers DS, McIntyre JO, VanSaun M, Wright JK, Matrisian LM, Brown HA. Characterization of Changes in Lipid Species During Progression of Human Non-alcohoholic Fatty Liver Disease (NAFLD) and in a Murine Model. PLoS ONE 2011; 6(8):e22775. PMID 21857953 48. Kyu LI, Hun J, Kyung PK, Young CD, Suk LY, Youn S, Gorden DL, Jun-Gi K, Teak O, « Is conservative treatment with antibiotics the correct strategy for treatment of right colonic diverticulitis? A prospective study » J Korean Soc Coloproctol. 2011 Aug; 27(4):188-93. Epub 2011 Aug31. PMID: 21980589 49. Kyu LI, VanSaun M, Jung HS, Matrisian LM, Gorden DL. “Increased Metastases are Associated with Inflammation and Matrix Metalloproteinase-9 Activity at Incision Sites in a Murine Model of Peritoneal Dissemination of Colorectal Cancer.” JSURGRES-D-11-01289R1. http://dx.doi.org/10.1016/j.jss.2012.04.074 50. Faitot F, Vibert E, Salloum C, Gorden DL, Coscas F, Adam R, Castaing D. “Importance of conserving middle hepatic vein distal branches for homogeneous regeneration of the left liver after right hepatectomy.” 2012 Nov;14(11):746-53. doi: 10.1111/j.1477-2574.2012.00514.x. Epub. 2012 Jun 27. Van Saun, MN, Mendosa AM, Gorden DL “Hepatocellular Proliferation Correlates with Inflammatory Cell and Cytokine Changes in a Murine Model of Nonalcoholic Fatty Liver Disease.” PlosOne. Sept 10, 2013. 51. Mistry AM, Gorden DL, Busler JF, Coggan AC, Kelly BS. “Diagnostic and Therapeutic Challenges in Hepatic Epithelioid Hemangioendothelioma.” J Gastrointest Canc 2012 Apr 29; doi: 10.1007/s 12029-012-9389-y Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 17 52. Caserta M, Sakala M, Shen P, Gorden DL, Wile G. “Presurgical Planning for Hepatobiliary Malignancies: Clinical and Imaging Consideration.” MRI Clinic of North America, August 2014. 53. Clark Kensinger, Kevin W. Sexton, Christopher M. Baron, Andrew J. Lipnik, Steven G. Meranze D. Lee Gorden Management of Portal Vein Thrombosis After Liver Transplantation with a Combined Open and Endovascular Approach. Liver Transplantation (in press). 54. D. Lee Gorden, David S. Myers, Pavlina T. Ivanova, Eoin Fahy, Mano R. Maurya, Shakti Gupta, Jun Min, Nathanael J. Spann, Jeffrey G. McDonald, Samuel L. Kelly, Jingjing Duan, M. Cameron Sullards, Thomas J. Leiker, Robert M. Barkley, Oswald Quehenberger, Aaron M. Armando, Stephen B. Milne, Thomas P. Mathews, Michelle D. Armstrong, Chijun Li, Willie V. Melvin, Ronald H. Clements, M. Kay Washington, Alisha M. Mendonsa, Joseph L. Wiztum, Ziqiang Guan, Christopher K. Glass, Robert C. Murphy, Edward A. Dennis, Alfred H. Merrill Jr., David W. Russell, Shankar Subramaniam, H. Alex Brown. Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. J Lipid Res2015 Mar;56(3):722-36. Doi: 10.1194/jlr.P056002 Epub 2015 Jan 17. 55. Mendonsa AM, VanSaun MN, Ustione A, Piston DW, fingleton BM, Gorden DL. Host and tumor derived MMP13 regulate extravasation and establishment of colorectal metastases in the liver. Mol Cancer 2015 Feb 22; 14:49. Doi: 10.1186/s12943-014-0282-0. PMID: 25880591. 56. Alisha M. Mendonsa Madeleine C. Chalfant, Lee D. Gorden, Michael N. VanSaun. Modulation of the Leptin Receptor Mediates Tumor Growth and Migration of Pancreatic Cancer Cells, Research Article. Published 28 Apr 2015. PLOS ONE 10.1371/journal.pone.0126686. 57. Hugo Bonatti, Brian Craig, Nithin Theckumparampil John Tarpley, Nadja Colon, Addison, May, D. Lee Gorden. Bordetella bronchiseptica pneumonia post liver resection in a patient with liver cirrhosis and cholangiocarcinoma. Surgical Infections, 1.1:112-114, 2016. 58. Fanuel Messagio, Alisha Mendonsa, Chanjuan Shi, Jason Castellanos Andrew Lowy, Nagaraj Nagathihalli, Nipun Merchant, D. Lee Gorden, and Michael N. VanSaun. Adiporon suppresses cytokine induced pSTAT3 and inhibits pancreatic cancer growth. Oncotarget. (in press). Articles Submitted for Publication 1. Castaing D, Vibert E, Ricca L, Gorden DL, Azoulay D, Adam R, Gayet B. Oncologic Results of Laparoscopic Versus Open Hepatectomy For Colorectal Liver Metastases In Two Specialized Centers. Annals of Surgery, (submitted). 2. Benkabbou A, Hoti E, Gorden DL, Levesque E, Hammad E, Rangeard AS, Castaing D, Azoulay D. Mesenterico-portal Vein Injury Managed by Endovascular Stenting: A Novel Approach to a Complex Intra-abdominal Injury. Cardiovascular and Interventional Radiology, (submitted). 3. Vibert E, Cotta F, Gorden DL, Castaing D, Aloia T, Carbonaro A, Metairie S, Adam R, Samuel D, Azoulay D. Portal Stenting for Hepatocellular Carcinoma Complicated by Portal Vein Invasion in Cirrhotic Patients: Report of a 7 Year Experience. Journal of Hepatology, (submitted). 4. Min Y, Li J, Boelte K, Huang J, Mosse CA, Gorden DL, Ren X, Li, Lin C. C/EBP- Regulates the Expansion of Gr-1+CD1 1b+ Myeloid Immune Suppressors Tumor Progression. Cancer Research (submitted). Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 18 Articles Submitted for Publication (continued) 5. Wenwei Yan, Qiang Gao, Lian Li Ma, Sunil K. Geevarghese, John Kelly Wright, Gorden DL Burnett S. Kelly, Wei Han, Roger Sciammas, and Deng Ping Yin. A Critical Role of B cells in Assisting Allograft Rejection in the Deficiency of PKC-theta. Transplantation, (submitted). Chapters 1. Gorden DL, Tuttle T. Cancer of the Colon and Rectum. In: Lee K and Dyke C, eds. Surgical Attending Rounds (2nd edition). Philadelphia: Lea Febiger, 1998. 2. Gorden DL, Taylor B, Langer B. The Management of Hepatic Echinococcosis. In: Cameron J, ed. Current Surgical Therapy (7th edition). Mosby, 2001. 3. Gorden DL, Tuttle T. Cancer of the Colon and Rectum. In: Lee K and Dyke C, eds. Surgical Attending Rounds (3rd edition). 2004. Abstracts and Presentations 1. Gorden DL, Robert A, Carpentier JL. Retardation of 125I-insulin Dissociation in Cells from a Patient with Leprechaunism (Lep/Ark-1): Correlation with a Quantitative Defect in Morphology of the Cell. Proceedings of the Endocrine Society, 1985. Presented at: The Endocrine Society, Baltimore, Maryland, 1985. 2. Pacheco R, Gorden DL. Tipificación del Menu Cotidiano de Campesinos de la Sierra. Proceedings of XI Congresso Medico Nacional, April 1987. Presented at: The Congreso Medico Nacional, Quito, Ecuador, 1987. 3. Sandoval, Fierro R, Pacheco R, Gorden DL. Corrección de la Deficiencia de Yodo (DY) y Mortalidad Infantil (MI). Proceedings of XI Congresso Medico Nacional, April, 1987. Presented at: The Congreso Medico Nacional, Quito, Ecuador, 1987. 4. Gorden DL, Mandriota SJ, Montesano R, Pepper MS. Modulation of Vascular Endothelial Growth Factor Expression in Isolated Rat Islets of Langerhans. Proceedings of the European Society for Clinical Investigation, April, 1996. Presented at: The European Society for Clinical Investigation International Congress, Interlaken, Switzerland, 1996. 5. Gorden DL, Delaney JP. Familial Association of Hashimoto’s Thyroiditis and Papillary Carcinoma of the Thyroid. Society for Endocrine Surgery. (1998). 6. Sanabria JR, O’Neil S, Gorden DL, Cattral MS, Grant D, Hemming AW, Greig PD. Incidence, Etiology, and Risk Factors for Biliary Complications after Adult Liver Transplantation. Proceedings of the Canadian Society for Transplantation. Abstract. 7. Gorden DL, Lynch CC, Fingleton B, Crawford HC, Matrisian LM. Differential Expression of Matrix Metalloproteinases in Primary Colorectal Tumors and Liver Metastases in an Orthotopic Murine Model: Potential Targets for Modulating the Growth of Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 19 8. Colorectal Liver Metastases. American Association of Cancer Research Bulletin: Protease Meeting. Abstract and Presentation. 9. Laparoscopic ultrasound guided radiofrequency ablation of liver tumors; Faculty Speaker Vanderbilt University School of Medicine Nashville, TN, April 2002. 10. Gorden DL. The Proteases and Cancer: Biology and Therapeutics Workshop. Presentation National Cancer Institute, Bethesda, MD. November, 2002. 11. Wise PE, Feurer I, Liou SS, Sulur P, Moore D, Meranze SG, Mazer MJ, Wright JK, Chari RS, Gorden DL, Strickland C, Pinson CW. Hepatic Artery Metastases to the Liver. 4th Americas Hepato-Pancreato-Biliary Congress, Miami Beach, FL. Chemoembolization for Isolated Colorectal Poster. February 27-March 2, 2003. 12. Moore DE, Feurer ID, Speroff T, Gorden DL, Wright JK, Chari RS, Pinson CW. Impact of Donor, Technical, and Recipient Risk Factors on Survival and Quality of Life after Liver Transplantation. 4th Americas Hepato-Pancreato-Biliary Congress, Miami Beach, FL. Presentation. February 27- March 2, 2003. 13. Anderson CD, Meranze S, Bream P, Gorden DL, Wright JK, Pinson CW, Chari RS. Portal Vein Embolization for Redo Hepatectomy in the Setting of Steatosis. Southeastern Surgical Congress. Abstract. 2003. 14. Moore DE, Feurer ID, Holzman MD, Wudel LJ, Strickland C, Gorden DL, Chari R, Wright JK, Pinson CW. Long-Term Detrimental Effect of Bile Duct Injury on Health- Related Quality of Life. Western Surgical Association Meeting, Tucson, AZ. Poster and presentation. November 8, 2003. 15. Gorden DL. Host Tumor Interactions and the Role of Matrix Metalloproteinases in Colorectal Cancer: Potential Targets for Modulating Metastatic Growth. Vanderbilt University Section of Surgical Sciences Research Conference. Presentation. November 21, 2003. 16. Anderson CD, Meranze S, Bream P Jr., Gorden DL, Wright JK, Pinson CW, Chari RS. Contralateral Portal Vein Embolization for Hepatectomy in the Setting of Hepatic Steatosis. Southeastern Surgical Congress Annual Meeting, Atlanta, GA. Presentation. January 31-February 3, 2004. 17. Acuff H, Fingleton B, Gorden DL, Chen X, Pozzi A., Matrisian LM. Establishment of Orthotopic Models of Lung Cancer to Analyze Host MMP Contributions to Lung Tumor Development. American Association for Cancer Research: 95th Annual Meeting, Orlando, FL. Abstract. March 27—31, 2004. 18. Gorden DL, Fingleton B, Lynch C, Juliao S, Matrisian LM. The Role of Matrix Metalloproteinases (MMP-9) in the Proliferation of Colorectal Cancer Metastases to the Liver. American Association for Cancer Research: 95th Annual Meeting, Orlando, FL. Abstract and presentation. March 27—31, 2004. 19. Moore DE, Poulose B, Grogan E, Speroff T, Feurer ID, Gorden DL, Chari TS, Wright JK, Pinson CW. Use of Donors Over 60 Years Old in Liver Transplantation: A Decision and Cost- Effectiveness Analysis. Presented, March, 2004 to the Annual Meeting of the American College of Surgeons, Journal of the American College of Surgeons, 2004, 199 (3S), S69. Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 20 20. Gorden, DL. Living Donor Liver Transplantation. Vanderbilt University Surgical Grand Rounds, Nashville, TN. Presentation, April 9, 2004. 21. Moore D, Feurer I, Speroff T, Rodgers S Jr., Shaffer D, Nylander W, Kizilisik T, Butler J, Ninan M, Awad J, Gorden DL, Chari R, Wright J, Pinson CW. Is There Racial Disparity in Outcomes Following Solid Organ Transplantation? Association of VA Surgeons, Richmond, VA. Presentation, April 26, 2004. 22. Gorden, DL. New Strategies for the Clinical Application of Matrix Metalloproteinase Inhibitors. Eastern Cooperative Oncology Group Spring Meeting, Boston, MA. Keynote lecture, May 13-16, 2004. 23. Thomas KT, Wright JK, Gorden DL, Chari RS, Feurer I, Pinson CW. Biliary Reconstruction Utilizing VCS™ Clips versus Conventional Sutured Anastomosis in Orthotopic Liver Transplant. American Hepato-Pancreato-Biliary Association Meeting, Washington, DC. Abstract, June 2—6, 2004. 24. Gorden DL, Jansen D, Lepage M, Matrisian LM. In Vivo Bioluminescence and MRI Imaging of Colorectal Cancer Metastases in Orthotopic Murine Models. American Hepato-Pancreato-Biliary Association Meeting, Washington, DC. Abstract, June 2—6, 2004. 25. Thomas KT, Welch D, Wise P, Gorden, DL, Chari RS, Wright Jr., JK, Washington K, Pinson CW. Treatment of Biliary Cystadenoma. Presented at the Southern Surgical Association, December 2004, Palm Beach, FL (submitted – Annals of Surgery, Nov 2004). 26. Austin MT, Feurer ID, Chari RS, Gorden, DL, Wright JK, Pinson CW. Survival After Pediatric Liver Transplantation: Why Does Living Donation Offer An Advantage? Presented at the 112th Scientific Session of the Western Surgical Association, November, 7-10, 2004. 27. Moore D, Poulose B, Speroff T, Feurer ID, Gorden DL, Chari RS, Wright JK, Pinson CW. Predicting Post-Transplant Graft Survival in Liver Transplant Recipients Using Perioperative Characteristics Under the New MELD System, Presented at the 2004 World Congress of International Hepatopancreatobiliary Association, HPB 2004, 6:21-22. 28. Moore DE, Carpenter RO, Pinson CW, Chari RS, Wright JK, Gorden DL. Liver Transplantation as a Treatment for Diffuse Hepatic Adenomatosis: Case Report of a 23 Year Old Female. Society of University Surgeons, Nashville, TN., Poster Presentation, February 2005. 29. Thomas KT, Welch D, Gorden DL, Chari RS, Wright Jr., JK, Washington K, Pinson CW. “Effective Treatment of Biliary Cystadenomas”. Surgery Grand Rounds – 31st Annual Barney Brooks Lecture, H. William Scott, Jr., Society. Vanderbilt University School of Medicine, April 8, 2005. 30. Gorden DL, Buchanan FG, Everest S, Matrisian LM. Inhibition of COX-2 Decreases Colorectal Cancer Metastases to the Liver in an Orthotopic Murine Model. 2005 “Proceedings of the American Association for Cancer Research”. Presented at the 96th Annual Meeting of the American Association for Cancer Research in Anaheim, California, April 16—20, 2005. Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 21 31. Iglesias-Marquez RA, Chapman WC, Kercher K, Matthews BD, Gorden DL, Brunt LM. “Previously Unreported High Grade Complications of Laparoscopic Adrenalectomy”. Presented – Society of American Gastrointestinal Endoscopic Surgeons (SAGES), 2005 Annual Meeting; Ft. Lauderdale, FL, April 13—16, 2005. 32. Moore DE, Feurer ID, Gorden DL, Wright Jr. JK, Chari RS, Pinson CW. Predicting post-transplant graft survival in liver transplant recipients using perioperative characteristics under the MELD system. Presented at the 2005 Clinical Congress of the American Hepato-Pancreato-Biliary Association; Hollywood, FL April 14—17, 2005. 33. Gorden DL. “Considering the Role of Host Stroma in Metastasis”. Section of Surgical Sciences, Research Conference, Vanderbilt University Medical Center, October 28, 2005. 34. Quarles CC, McIntyre O, Gorden DL, Lepage MD, Yankeelov TE, Price RR, Matrisian LM, Gore JC. “Functional Colonoscopy Using Dark Lumen Dynamic Contrast Enhanced MRI”. (Accepted – The International Society for Magnetic Resonance in Medicine, November, 2005). 35. Schrager JJ, Wright K, Chari RS, Pinson CW, Austin MT, Gorden DL. “The Use of Recombinant Factor VIIA for Management of hemorrhage in Cirrhotic Patients, Pre-Liver Transplant”. Poster presentation at the Southeastern Surgical Congress, Gold Medal Forum Panel, Lake Buena Vista, FL, February 18-21, 2006. 36. Earl TM, Wright JK, Gorden DL, Pinson CW, Raiford DS, Porayko MK, Geevarghese S, Kelley B and Chari RS. “Liver Transplantation for non-Hepatocellular Carcinoma and non- Cholangiocarcinoma Neoplasms in the MELD Era”. Presented at the 2006 AHPBA Spring Meeting, Eden Roc Resort, Miami Beach, Florida, March 3-9, HPB: 8(supp. 1): 85, 2006. 37. Kelly BS, Wright JK, Gorden DL, Geevarghese SG, Wright CW, Chari RS. “Optimizing Donor- Recipient Pairing Improves Liver Transplant Graft Survival”. Presented at the 2006 AHPBA Spring Meeting, Eden Roc Resort, Miami Beach, Florida, March 3-9, HPB: 8(supp. 1): 25, 2006. 38. Gorden DL. “Management of Colorectal Cancer Metastases”. Presented at the Virginia Piper Cancer Institute, Current Therapy and Future Opportunities, March, 2006. 39. Gorden DL, Im JH, Fu W, Matrisian LM, Muschel R. “Use Of Multiphoton Microscopy To Study Early Steps In Metastasis” Presented at the 97th American Association Cancer Research annual spring meeting, Washington DC, April 1-5, 2006. 40. Buchanan G, Gorden DL, Matta P, Shi Q, Matrisian L, DuBois R. “Role of B-arrestin-1 in the Metastatic Progresión of Colorectal Cancer”. Presented at the 97th American Association Cancer Research 2006 annual meeting, Washington, DC, April 1-5. Published in the Proceedings of the American Association of Cancer Research. 41. Iglesias-Marquez RA, Chapman WC, Kercher K, Matthews BD, Gorden DL, Brunt LM. “Previously Unreported High Grade Complications of Adrenalectomy”. Poster presentation at the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Hilton Anatole in Dallas, Texas, April 26-29, 2006 for the 2006 Surgical Spring Week. Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 22 42. Castaldo ET, Pinson CW, Feurer ID, Wright Jr. JK, Gorden DL, Kelly BS, Chari RS. “Continuous vs. Interrupted Suture Technique for End-to-End Biliary Anastomosis During Liver Transplantation Give Equally Good Results.” Concurrent Session 80: Surgical Techniques: New Ways to Look at Old Problems. World Transplant Congress, Boston, MA July 26, 2006. American Journal of Transplantation, 2006 August; 6 (S2) and Transplantation, 2006 July; 82 (issue 1) (S3):389. 43. Castaldo ET, Pinson CW, Feurer ID, Wright JK, Gorden DL, Kelly BS, Chari RS. “Continuous vs. Interrupted Suture Technique for end-to-End Biliary Anastomosis During Liver Transplantation Give Equally Good Results.” Poster presentation: 7th World Congress of the International Hepato-Pancreato- Biliary Association. Sept. 3-7, 2006. Edinburgh, Scotland, HPB, 2006 September; 8(S2): 137-138. 44. Nicoud IB, Jones CM, Pierce JM, Earl TM, Matrisian LM, Gorden DL, Chari RS. “Warm Hepatic Ischemia-Reperfusion Promotes MMP9-dependent Growth of Metastatic Colorectal Carcinoma in the Liver”. Abstract and Poster, The 2nd Academic Surgical Congress, February 6-9, 2007. Journal of Surgical Research, 2007 February; 137(2):225. 45. Gorden DL, McIntyre JO, Everest S, Matrisian LM. “Steatosis Promotes Metastatic Tumor Growth in the Hepatic Microenvironment. 4th International Conference on Tumor Microenvironment: Progression, Therapy & Prevention, Poster Presentation – Verona, Italy, March 6-10, 2007, American Association for Cancer Research. 46. Im JH, Gorden DL, Fu W, Hill S, Bernhard E, Muschel R.“Imaging of Tumor Progression and Metastasis”. American Association Cancer Research 2007 annual meeting, Los Angeles, CA April 14-18. Proceedings of the American Association of Cancer Research, poster presentation. 47. Koller F, Guillamondegui O, Chari RS, Geevarghese SK, Kelly BS, Wright Jr. JK, Gorden DL. “Current Management of Pyogenic Abscesses of the Liver.” (Proceedings of the Southeastern Surgical Congress, 2007). 48. Muschel RJ, Im J, Gorden DL, Fu W, Smart S, Hill S. “The Role of the Host in Organ Specific Metastasis: Lung, Liver and Brain”. Tumor Vasculature Interactions – Conference, Munich, Germany, September 2007. 49. Gorden DL, VanSaun M, McIntyre JO, Everest S, Matrisian LM. “Steatotic Liver Microenvironment Promotes the Growth of Colorectal Cancer Metastases.” American Association Cancer Research meeting: Advances in Colon Cancer Research, November 14 – 17, 2007, Hyatt Regency Cambridge, Cambridge, MA Proceedings of the American Association of Cancer Research. 50. Van Saun MN, Lee IK, Washington K, Matrisian LM, Gorden DL. “A High Fat Diet Leads to the Development of Primary Dysplasia and Increases the Metastatic Tumor Burden in the Murine Liver”. Poster presentation at The American Cancer Society meeting, Ashville, NC, April, 2008. 51. Im, JH, Gorden DL, Hill S, Smart S, Noterdaeme O, Brady M, Augustin HG, Bernhard E, Muschel R. “Effects of Host Vascular Modifications on Colony Development in the Liver”. Post presentation – American Association of Cancer Research, April 12-16, 2008, San Diego, CA. 52. Dykes J, Feurer I, Ball J, Wisiwatapnimit P, Pinson CW, Gorden, DL. “Post- Transplant Employment Is Not Influenced By The MELD System”. American Transplant Congress Proceedings Post presentation at the 2008 American Transplant Congress; Metro Toronto Convention Centre, Toronto, Canada, May 31—June 4, 2008. Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 23 53. Lee IK, Jung SE, Gorden DL, Lee YS, Jung DY, Oh ST, Kim JG,Jeoon HM, Chang SK. “The Diagnostic Criteria for Right Colonic Diverticulitis: Prospective Evaluation of 100 Patients.” Post presentation – “Awarded Poster of Distinction”, American Transplant Congress Annual Meeting and Scientific Sessions; Metropolitan Toronto Convention Centre, Toronto, Canada, May 31—June 4, 20 54. VanSaun MN, Lee IK, Washington K, Matrisian LM, Gorden DL. “The Steatotic Microenvironment Augments Metastatic Tumors in a Murine Model.” American Association for Cancer Research, Conference on Metastasis August 3-7, 2008, Vancouver, BC, Canada. (Accepted for poster presentation) 55. Martin MD, Kremers GJ, Rocheleau JN, Piston DW, Matrisian LM, Gorden DL. “Breast Cancer Metastases Rapidly Extravasate from the Vasculature in a Murine Model of Liver Metastasis.” American Association for Cancer Research Conference on Metastasis August 3-7, 2008, Vancouver, BC, Canada. (Accepted for poster presentation) 56. Kappa SF, Gorden DL, Davidson MA, Wright JK, Guillamondegui OD. “Predictors of Postoperative Hemorrhage and the Application of Open Abdomen in Orthotopic Liver Transplantation.” (American Society of Transplantation Congress, 2009). 57. Bouchahda M, Karaboué A, Saffroy R, Innominato P, Gorden DL, Guettier C, Adam R, Lévi F. Acquired KRAS Mutations During Progression of Colorectal Cancer Metastases: Possible Implications for Therapy and Prognosis. Submitted for the 2010 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium (January 22- 4, 2010). 58. Kappa S, Gorden DL, Wright JK, Guillemondegui O. Predictors of Postoperative Hemorrhage in Orthotopic Liver Transplantation. Proceedings of the Southeastern Surgical Congress February 20-23 in Savannah, GA. 59. VanSaun MN, Lee IK, Matrisian LM, Gorden DL. Matrix Metalloproteinases Impact Metastatic Growth in the Liver Microenvironments of Steatosis and Steatohepatitis. Proceedings of The 5th International Conference on Tumor Microenviroment, October 20-24, 2009, Versailles, France. 60. Lee IK, VanSaun MN, Matrisian LM, Gorden DL. The Effects of Inflammation on the Metastatic Microenvironment: Peritoneal Metastasis in a Mouse Model with Abdominal Incision Wound. Proceedings of the 5th International Conference on Tumor Microenviroment, October 20-24, 2009, Versailles, France. 61. Vibert E., Castaing D., Perdigao Cotta F., Khalfallah M., Gorden DL, C. Salloum, Adam R., Azoulay D. Results of Portal Vein Metallic Stent Placement in Patients with Portal Vein Tumor Thrombus Complicating Hepatocellular Carcinoma, Proceedings of the International Hepatobiliary Association, 2010. 62. Agostini J, Vibert E, Veilhan LA, Gorden DL, Hoti E, Azoulay D, Castaing D, Bismuth H, Adam R. Long Term Results of Surgical Resection for Treatment Setting of Normal Liver. Proceedings of the International Hepatobiliary Association, 2010.of Hepatocellular Carcinoma in the 63. Martineau I, Vibert E, Gorden DL, Awad S, Serna S, Adam R, Castaing D, Bellin MF, Azoulay D. Utility of Routine CT Arteriography (CTA) in the Diagnosis of Early Arterial Complications Following Adult Liver Transplantation. Proceedings of The International Hepatobiliary Association, 2010. Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 24 64. Abenkabbou E, Bucur VP, Gorden DL , Salloum C, Pascal G, Adam R, Azoulay D, Castaing D. Results of a Multidisciplinary Approach for Biliary Symptoms Following Failed Primary Hepaticojejunostomy in the Setting of Benign Disease. Proceedings of The International Hepatobiliary Association, 2010. 65. Levesque E, Vibert E, Salloum C, Benkabbou A, Gorden DL, Adam R, Castaing D. Azoulay SD. Impact on Early Post-operative Outcome Following Liver Transplantation of Grafts Larger Than 2% of the Recipient’s Body Weight. Proceedings of The International Hepatobiliary Association, 65. 2010. 66. Bucur P, Vibert E, Benkabbou A, Gorden DL, Salloum C, Adam R, Azoulay D. Castaing. D. Longterm Outcome of Hepatectomy for Primary Intrahepatic Cholelithiasis in a European Referral Center. Proceedings of the International Hepatobiliary Association, 2010. 67. Gorden DL. Surgical Grand Rounds, University of Geneva School of Medicine, Hospital Cantonal de Geneve, December 15, 2009. “Combined Liver Kidney Transplantation: scope of the issue and ongoing debate”. 68. Martin, MD, Kremers, GJ, Short, KW, Rocheleau, JV, Piston, DW, Matrisian, LM, Gorden DL. Analysis of the Extravasation and Establishment of Breast Cancer Micrometastases In the Liver. Abstract and poster in the Proceedings of American Association of Cancer Research Joint Meeting with The Metastasis Research Society, Philadelphia, PA September 2010. 69. VanSaun MN, Lee IK, Mendonsa A, Matrisian LM, Gorden DL. Establishment of Hepatic Metastases in a Steatotic Microenvironment is Enhanced by Stromal Derived MMP12. Poster presentation, National Tumor Microenvironment Meeting, Bethesda, MD July 7-9 2010. 70. Gorden DL, Topic: “Molecular Determinants of Tumor Progression in a Steatotic Microenvironment.” Invited Speaker, National Tumor Microenvironment Meeting, Bethesda, MD July 7, 2010. 71. VanSaun MN, Lee IK, Mendonsa A, Matrisian LM, Gorden DL. Establishment of Hepatic Metastases In a Steatotic Microenvironment is Enhanced By Stromal Derived MMP12. Proceedings of the AACR Scientific Meeting, Washington, D.C., April 2010, (poster and abstract). 72. Van Saun MN, Mendonsa A, Lee IK, Matrisian LM, Gorden DL. Increased Hepatic Metastases are associated with Up Regulation of MMP12 and Inflammatory Cell Infiltration In The Microenvironment of Steatohepatitis. Proceedings of AACR Tumor Immunology Meeting, Miami, FL. December 2010, (poster and abstract). 73. Mendonsa A, Van Saun MN, Matrisian LM, Gorden DL. Role of MMP13 in the Steatotic Liver Microenvironment. Vanderbilt University Cancer Biology Retreat, November 2010. 74. Gorden DL, Chanjuan Shi, Kay Washington and Michael N. VanSaun. Increases In Pancreatic Adipose Tissue Are Associated With Growth of Primary Pancreatic Cancer. Proceedings of American Society of Gastroenterology, presented poster Digestive Disease Week May 2011. 75. Alisha Mendonsa, Michael N. VanSaun, Lynn M. Matrisian, Gorden DL. “Role of MMP13 in the Steatotic Liver Microenvironment,” presented at MMP Gordon Conference, Smithfield, RI August, 2011. Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 25 76. Diagnosis and Treatment of Hepatocellular Carcinoma: Responding To a Growing Clinical Challenge VUMC Gastroenterology and Hepatology Update September 2011, Invited Faculty Speaker. 77. Debate: Adult-to-Adult Living Donor Liver Transplantation: Worth the Risk? Pro: Andy Scanga/Con: Gorden DL. VUMC School of Medicine. October 21, 2011, Invited Faculty Speaker. 78. Alisha Mendonsa, Madeleine Chalfant, Nagaraj Nagathihalli, Nipun Merchant, Gorden DL, and Michael Van Saun. Modulation of Leptin Receptor in Pancreatic Cancer Cells Alters Tumor Proliferation in Vitro and in Vivo. American Association for Cancer Research, April 2012. 79. Mendonsa A, VanSaun MN, Chalfant M, Matrisian LM, and Gorden DL. MMP12 and Myeloid Cell Populations Influence Establishment of Tumor Metastases in the Steatotic Liver Microenvironment. American Association for Cancer Research, April 2012. 80. NIDDK supported VUMC Digestive Disease Research Center Pilot & Feasibility Application April 2012, selected Tertiary Reviewer. 81. McElmurray, Bream P., Grzeszczak, Gorden DL, Feurer I., Berlin J., Meranze. Phase II Clinical Trial of Yttrium-90 Resin Microspheres for the Treatment of Metastatic Neuroendocrine Tumor: Extended Follow-up. World Congress of Interventional Oncology. Chicago, IL. 2012. 82. Mendonsa A, Van Saun MN, Chalfant M, and Gorden DL. “Role of MMP13 in the Steatotic Liver Microenvironment”. VICC Retreat “New Horizons in Lung Cancer Research.” May 2012. 83. Alisha Mendonsa, Madeleine Chalfant, Gorden DL, and Michael N. Van Saun. Adiponectin Deficiency Enhances Pancreatic Cancer Growth. AACR Pancreatic Cancer Research. Lake Tahoe, NV. June 2012. 84. “Molecular Mechanisms of Tumor Progression in a Steatotic Liver Microenvironment” VUMC P20 Scientific Retreat, Invited Faculty Speaker, June 2012. 85. “Surgical Perspectives on Liver Transplantation.” VUMC, Invited Faculty Speaker, September 4, 2012. 86. Lynn E. Samuelson, Alisha Mendosa, Michael N. VanSaun, Darryl J. Bornhop, J. Oliver McIntyre, D. Lee Gorden. Ultra-Sensitive Detection of Hepatocellular Carcinoma Biomarkers In Urine Using Backscatter Interferometry. Vanderbilt University Imaging Institute Retreat, 2013. 87. Lynn E. Samuelson, J. Oliver McIntyre, Darryl J. Bornhop, D. Lee Gorden. Ultra-Sensitive Detection of Hepatocellular Carcinoma Biomarkers in Urine using Backscatter Interferometry, Frontiers in Biomedical Imaging Conference, May 2013. 88. Alisha M. Mendonsa, Michael N. VanSaun, Madeleine Chalfant, Lynn M. Matrisian, D. Lee Gorden. MMP13 Contributes To Tumor Metastasis in the Steatotic Liver Microenvironment. MMP Gorden Research Conference, Florence, Italy, May 2013. 89. Lynn E. Samuelson, Michael Kammer, Alisha Mendonsa, Michael N. VanSaun, Darryl J. Bornhop, J. Oliver McIntyre, D. Lee Gorden. Ultra-Sensitive Detection of Hepatocellular Carcinoma Biomarkers in Urine using Backscatter Interferometry. Vanderbilt Institute of Imaging Sciences Retreat, June 2013. Curriculum Vitae David Lee Gorden, M.D., F.A.C.S. 26 90. Gorden DL. NAFLD: Improving diagnostics and refining prognosis for a clinical epidemic. McGill Clinical and Applied Proteomics Workshop October 25, 2013. 91. Liver Transplantation: the surgical procedure. DL Gorden. Invited lecturer, Hepatology Core Curriculum Series VUMC, 2012, 2013, 2014, 2015, 2016. 92. Management of Portal Vein Thrombosis post Liver Transplant. DL Gorden, Invited Lecturer, International Symposium on Innovative Expert Hepatobiliary Surgery, Jornadas Internacionails de Cirugia, May 29, 2014, Coimbra, Portugal. 93. Heather W. O’Dell, Roman E. Perri, Anthony D. Dreher, D. Lee Gorden. Low long term tumor recurrence and mortality rates in patients transplanted for hepatocellular carcinoma listed with low native MELD scores. Proceedings of the American Association of Liver Disease (AASLD) meeting, Boston, MA 2016. 94. Kensinger, Clark, Geevhargese, Sunil, Gorden, D. Lee Complex Portal Venous Inflow Reconstruction in Liver Transplantation: The Option of Left Renal –Portal Vein Transposition AHPBA Annual meeting, Miami, FL, April 2017. 95. Heather W. O’Dell, Joseph A. Awad, Sunil K. Geevarghese, D. Lee Gorden, Katie E. Hafner, Katie L. Roll, Roman E. Perri, Michael K. Porayko, Alison R. Rafferty, Andrew E. Scanga, Natasha J. Schneider, J. Kelly Wright, Jr., Chan Y. Chung. Retrospective Review of Liner Transplantation of UNOS-Defined Hepatitis C Positive Donors into Hepatitis C Naϊve Recipeints. AASLD 2017. 96. Haglund JW, Conteh LF, Laskey HLJ, Kensinger CD, Wall A, Slaughter JC, Campbell KE, Dean MJ, Gorden DL, Scanga AE. Stent or no stent? A randomized controlled trial comparing the incidence of biliary complications after liver transplantation, interim analysis. AASLD 2017.